2nll Summary

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RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA

The structure was published by Rastinejad, F., Perlmann, T., Evans, R.M., and Sigler, P.B., in 1995 in a paper entitled "Structural determinants of nuclear receptor assembly on DNA direct repeats." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This entry contains 12 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (RETINOIC ACID RECEPTOR) P19793 (135-200) (RXRA_HUMAN)search Homo sapienssearch 98% 66 100%
B PROTEIN (THYROID HORMONE RECEPTOR) P10828 (104-204) (THB_HUMAN)search Homo sapienssearch < 90% 103 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P19793 (135 - 200) PROTEIN (RETINOIC ACID RECEPTOR) Homo sapiens
P10828 (104 - 204) PROTEIN (THYROID HORMONE RECEPTOR) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P19793) Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch PF00105: Zinc finger, C4 type (two domains)search
B Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P19793) sequence-specific DNA binding transcription factor activitysearch zinc ion bindingsearch sequence-specific DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch
B (P10828) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch thyroid hormone receptor activitysearch zinc ion bindingsearch sequence-specific DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch
B Zinc finger, nuclear hormone receptor-typesearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch Zinc finger, NHR/GATA-typesearch