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RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA

X-ray diffraction
1.9Å resolution
PDB entry 2nll coloured by chain, front view.
PDB entry 2nll coloured by chain, side view.
PDB entry 2nll coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: RXRalpha-TRbeta nuclear hormone receptor complex and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 15005.36 Å2
Buried surface area: 6115.53 Å2
Dissociation area: 882.54 Å2
Dissociation energy (ΔGdiss): -3.37 kcal/mol
Dissociation entropy (TΔSdiss): 10.92 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115664

Macromolecules

Retinoic acid receptor RXR-alpha
Chain: A
Length: 66 amino acids
Theoretical weight: 7.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 135-200; Coverage: 14%)
Gene names: NR2B1, RXRA
Pfam: Zinc finger, C4 type (two domains)
InterPro:
CATH: Erythroid Transcription Factor GATA-1, subunit A
SCOP: Nuclear receptor
Retinoic acid receptor RXR-alpha in PDB entry 2nll, assembly 1, front view.
Retinoic acid receptor RXR-alpha in PDB entry 2nll, assembly 1, side view.
Retinoic acid receptor RXR-alpha in PDB entry 2nll, assembly 1, top view.
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Thyroid hormone receptor beta
Chain: B
Length: 103 amino acids
Theoretical weight: 12.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10828 (Residues: 104-206; Coverage: 22%)
Gene names: ERBA2, NR1A2, THR1, THRB
Pfam: Zinc finger, C4 type (two domains)
InterPro:
CATH: Erythroid Transcription Factor GATA-1, subunit A
SCOP: Nuclear receptor
Thyroid hormone receptor beta in PDB entry 2nll, assembly 1, front view.
Thyroid hormone receptor beta in PDB entry 2nll, assembly 1, side view.
Thyroid hormone receptor beta in PDB entry 2nll, assembly 1, top view.
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DNA chain C
Name: DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3')
Representative chains: C
Length: 18 nucleotides
Theoretical weight: 5.64 KDa
DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3') in PDB entry 2nll, assembly 1, front view.
DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3') in PDB entry 2nll, assembly 1, side view.
DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3') in PDB entry 2nll, assembly 1, top view.
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DNA chain D
Name: DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3')
Representative chains: D
Length: 18 nucleotides
Theoretical weight: 5.5 KDa
DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3') in PDB entry 2nll, assembly 1, front view.
DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3') in PDB entry 2nll, assembly 1, side view.
DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3') in PDB entry 2nll, assembly 1, top view.
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