› 2nae

Solution NMR

Membrane-bound mouse CD28 cytoplasmic tail

Released:
DOI: 10.2210/pdb2nae/pdb
PDB entry 2nae coloured by chain, ensemble of 10 models, front view.
PDB entry 2nae coloured by chain, ensemble of 10 models, side view.
PDB entry 2nae coloured by chain, ensemble of 10 models, top view.
Source organism: Mus musculus
Primary publication:
Dynamic regulation of CD28 conformation and signaling by charged lipids and ions.
Yang W, Pan W, Chen S, Trendel N, Jiang S, Xiao F, Xue M, Wu W, Peng Z, Li X, Ji H, Liu X, Jiang H, Wang H, Shen H, Dushek O, Li H, Xu C
Nat Struct Mol Biol 24 1081-1092 (2017)
PMID: 29058713

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151899 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell-specific surface glycoprotein CD28 Chain: A
Molecule details ›
Chain: A
Length: 43 amino acids
Theoretical weight: 5.09 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P31041 (Residues: 177-218; Coverage: 21%)
Gene name: Cd28

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

5 review citations

Molecular mechanisms of T cell sensitivity to antigen.
Siller-Farfán et al. (2018)
4 more