› 2mzx

Solution NMR

CCR5-ECL2 helical structure, residues Q186-T195

Released:
DOI: 10.2210/pdb2mzx/pdb
PDB entry 2mzx coloured by chain, ensemble of 11 models, front view.
PDB entry 2mzx coloured by chain, ensemble of 11 models, side view.
PDB entry 2mzx coloured by chain, ensemble of 11 models, top view.
Source organism: Homo sapiens
Primary publication:
An extended CCR5 ECL2 peptide forms a helix that binds HIV-1 gp120 through non-specific hydrophobic interactions.
Abayev M, Moseri A, Tchaicheeyan O, Kessler N, Arshava B, Naider F, Scherf T, Anglister J
FEBS J 282 1906-1921 (2015)
PMID: 25703038

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156397 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C chemokine receptor type 5 Chain: A
Molecule details ›
Chain: A
Length: 10 amino acids
Theoretical weight: 1.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51681 (Residues: 186-195; Coverage: 3%)
Gene names: CCR5, CMKBR5

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 37%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 citation in other articles

Investigation of Inhibition Mechanism of Chemokine Receptor CCR5 by Micro-second Molecular Dynamics Simulations.
Salmas et al. (2015)
4 more

2 mentions without citation

The TensorMol-0.1 model chemistry: a neural network augmented with long-range physics.
Yao et al. (2018)
1 more