› 2maw

Solution NMR

NMR structures of the alpha7 nAChR transmembrane domain.

Released:
DOI: 10.2210/pdb2maw/pdb
PDB entry 2maw coloured by chain, ensemble of 20 models, front view.
PDB entry 2maw coloured by chain, ensemble of 20 models, side view.
PDB entry 2maw coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Insights into distinct modulation of α7 and α7β2 nicotinic acetylcholine receptors by the volatile anesthetic isoflurane.
Mowrey DD, Liu Q, Bondarenko V, Chen Q, Seyoum E, Xu Y, Wu J, Tang P
J Biol Chem 288 35793-800 (2013)
PMID: 24194515

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153192 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuronal acetylcholine receptor subunit alpha-7 Chain: A
Molecule details ›
Chain: A
Length: 137 amino acids
Theoretical weight: 14.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P36544 (Residues: 228-326, 467-496; Coverage: 27%)
Gene names: CHRNA7, NACHRA7
Sequence domains: Neurotransmitter-gated ion-channel transmembrane region
Structure domains: Neurotransmitter-gated ion-channel transmembrane domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 73%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Understanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery.
Corradi et al. (2016)
4 more

9 mentions without citation

Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors.
Burgos et al. (2016)
8 more