2m55 Summary


NMR structure of the complex of an N-terminally acetylated alpha-synuclein peptide with calmodulin

The structure was published by Gruschus, J.M., Yap, T.L., Pistolesi, S., Maltsev, A.S., and Lee, J.C., in 2013 in a paper entitled "NMR Structure of Calmodulin Complexed to an N-Terminally Acetylated alpha-Synuclein Peptide." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Calmodulin and Alpha-synuclein.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calmodulin P62158 (2-149) (CALM_HUMAN)search Homo sapienssearch 97% 148 100%
B Alpha-synuclein P37840 (1-19) (SYUA_HUMAN)search Homo sapienssearch 100% 21 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62158 (2 - 149) Calmodulin Homo sapiens
P37840 (1 - 19) Alpha-synuclein Homo sapiens

Chain Sequence family (Pfam)
A (P62158) PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch
B (P37840) PF01387: Synucleinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P62158) calcium ion bindingsearch protein domain specific bindingsearch protein bindingsearch titin bindingsearch phosphatidylinositol 3-kinase bindingsearch ion channel bindingsearch adenylate cyclase bindingsearch type 3 metabotropic glutamate receptor bindingsearch N-terminal myristoylation domain bindingsearch enzyme regulator activitysearch metal ion bindingsearch phospholipase bindingsearch protein phosphatase activator activitysearch calcium-dependent protein bindingsearch thioesterase bindingsearch nitric-oxide synthase bindingsearch nitric-oxide synthase regulator activitysearch protein N-terminus bindingsearch cytosolsearch spindle polesearch calcium channel complexsearch nucleoplasmsearch cytoskeletonsearch nucleussearch plasma membranesearch sarcomeresearch extracellular vesicular exosomesearch centrosomesearch cytoplasmsearch spindle microtubulesearch spindlesearch extracellular regionsearch growth conesearch neuron projectionsearch Fc-epsilon receptor signaling pathwaysearch carbohydrate metabolic processsearch positive regulation of cyclic nucleotide metabolic processsearch fibroblast growth factor receptor signaling pathwaysearch regulation of cardiac muscle contractionsearch response to calcium ionsearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch membrane organizationsearch calcium-mediated signalingsearch regulation of cytokinesissearch innate immune responsesearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch epidermal growth factor receptor signaling pathwaysearch small molecule metabolic processsearch synaptic transmissionsearch nitric oxide metabolic processsearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch response to corticosteronesearch inositol phosphate metabolic processsearch muscle contractionsearch regulation of nitric-oxide synthase activitysearch glucose metabolic processsearch regulation of ryanodine-sensitive calcium-release channel activitysearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch response to amphetaminesearch signal transductionsearch platelet activationsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch detection of calcium ionsearch regulation of heart ratesearch activation of phospholipase C activitysearch phototransduction, visible lightsearch positive regulation of protein dephosphorylationsearch neurotrophin TRK receptor signaling pathwaysearch substantia nigra developmentsearch blood coagulationsearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch positive regulation of nitric-oxide synthase activitysearch glycogen catabolic processsearch G-protein coupled receptor signaling pathwaysearch regulation of rhodopsin mediated signaling pathwaysearch rhodopsin mediated signaling pathwaysearch regulation of high voltage-gated calcium channel activitysearch positive regulation of phosphoprotein phosphatase activitysearch activation of adenylate cyclase activitysearch platelet degranulationsearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
B Synucleinsearch