2m20 Summary

pdbe.org/2m20
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EGFR transmembrane - juxtamembrane (TM-JM) segment in bicelles: MD guided NMR refined structure.

The structure was published by Endres, N.F., Das, R., Smith, A.W., et al., Wemmer, D.E., Groves, J.T., and Kuriyan, J., in 2013 in a paper entitled "Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Epidermal growth factor receptor.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Epidermal growth factor receptor P00533 (642-697) (EGFR_HUMAN)search Homo sapienssearch < 90% 60 100%
B Epidermal growth factor receptor P00533 (642-697) (EGFR_HUMAN)search Homo sapienssearch < 90% 60 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00533 (642 - 697) Epidermal growth factor receptor Homo sapiens