› 2m0u

Solution NMR

Complex structure of C-terminal CFTR peptide and extended PDZ1 domain from NHERF1

Released:
DOI: 10.2210/pdb2m0u/pdb
PDB entry 2m0u coloured by chain, ensemble of 20 models, front view.
PDB entry 2m0u coloured by chain, ensemble of 20 models, side view.
PDB entry 2m0u coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Ligand-induced dynamic changes in extended PDZ domains from NHERF1.
Bhattacharya S, Ju JH, Orlova N, Khajeh JA, Cowburn D, Bu Z
J Mol Biol 425 2509-28 (2013)
PMID: 23583913

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127087 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 12.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14745 (Residues: 11-120; Coverage: 31%)
Gene names: NHERF, NHERF1, SLC9A3R1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
C-terminal CFTR peptide Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 633 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

5 review citations

Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures.
Ye et al. (2013)
4 more

1 mention without citation

Ligand-induced dynamic changes in extended PDZ domains from NHERF1.
Bhattacharya et al. (2013)