› 2lp7

Solution NMR

Structure of gp41-M-MAT, a membrane associated MPER trimer from HIV-1 gp41.

Released:
DOI: 10.2210/pdb2lp7/pdb
PDB entry 2lp7 coloured by chain, ensemble of 11 models, front view.
PDB entry 2lp7 coloured by chain, ensemble of 11 models, side view.
PDB entry 2lp7 coloured by chain, ensemble of 11 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimer.
Reardon PN, Sage H, Dennison SM, Martin JW, Donald BR, Alam SM, Haynes BF, Spicer LD
Proc Natl Acad Sci U S A 111 1391-6 (2014)
PMID: 24474763

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125898 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibritin C-terminal domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 59 amino acids
Theoretical weight: 7.01 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: M1E1E4 (Residues: 1-59; Coverage: 100%)
Sequence domains: Fibritin C-terminal region
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 19%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Algorithms for protein design.
Gainza et al. (2016)
4 more

9 mentions without citation

Oligomeric Structure and Three-Dimensional Fold of the HIV gp41 Membrane-Proximal External Region and Transmembrane Domain in Phospholipid Bilayers.
Kwon et al. (2018)
8 more