› 2leo

Solution NMR

Solution structure of esophageal cancer-related gene 2

Released:
DOI: 10.2210/pdb2leo/pdb
PDB entry 2leo coloured by chain, ensemble of 20 models, front view.
PDB entry 2leo coloured by chain, ensemble of 20 models, side view.
PDB entry 2leo coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure note: human esophageal cancer-related gene 2.
Feng Y, Geng Y, Zhou T, Wang J
J Biomol NMR 53 65-70 (2012)
PMID: 22528291

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157644 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease inhibitor Kazal-type 7 Chain: A
Molecule details ›
Chain: A
Length: 66 amino acids
Theoretical weight: 7.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P58062 (Residues: 20-85; Coverage: 100%)
Gene names: ECG2, SPINK7, UNQ745/PRO1474
Sequence domains: Kazal-type serine protease inhibitor domain
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 94%
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Cysteines and Disulfide Bonds as Structure-Forming Units: Insights From Different Domains of Life and the Potential for Characterization by NMR.
Wiedemann et al. (2020)

4 mentions without citation

Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis.
Azouz et al. (2020)
3 more