2len Summary


Solution structure of UCHL1 S18Y variant

The structure was published by Tse, H., Sze, K., and Hu, H., in in a paper entitled "Backbone and side-chain (1)H, (15)N and (13)C resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Ubiquitin carboxyl-terminal hydrolase isozyme L1. This molecule has the UniProt identifier P09936 (UCHL1_HUMAN)search. The sample contained 231 residues which is 100% of the natural sequence. Out of 231 residues 231 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ubiquitin carboxyl-terminal hydrolase isozyme L1 P09936 (1-223) (UCHL1_HUMAN)search Homo sapienssearch 100% 231 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P09936 (1 - 223) Ubiquitin carboxyl-terminal hydrolase isozyme L1 Homo sapiens

Chain Sequence family (Pfam)
A (P09936) PF01088: Ubiquitin carboxyl-terminal hydrolase, family 1search

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P09936) adult walking behaviorsearch sensory perception of painsearch ubiquitin-dependent protein catabolic processsearch axon target recognitionsearch cell proliferationsearch cell deathsearch response to ischemiasearch eating behaviorsearch negative regulation of MAP kinase activitysearch muscle fiber developmentsearch axonogenesissearch proteolysissearch neuromuscular processsearch axon transport of mitochondrionsearch protein deubiquitinationsearch nucleussearch nucleolussearch extracellular vesicular exosomesearch intracellularsearch cytosolsearch cytoplasmsearch plasma membranesearch endoplasmic reticulum membranesearch membranesearch neuronal cell bodysearch axonsearch endoplasmic reticulumsearch cysteine-type endopeptidase activitysearch hydrolase activitysearch ligase activitysearch ubiquitin-specific protease activitysearch ubiquitin thiolesterase activitysearch omega peptidase activitysearch protein bindingsearch alpha-2A adrenergic receptor bindingsearch cysteine-type peptidase activitysearch peptidase activitysearch ubiquitin bindingsearch

Chain InterPro annotation
A Peptidase C12, ubiquitin carboxyl-terminal hydrolasesearch