› 2le4

Solution NMR

Solution structure of the HMG box DNA-binding domain of human stem cell transcription factor Sox2

Released:
DOI: 10.2210/pdb2le4/pdb
PDB entry 2le4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2le4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2le4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Sahu SC, Markley JL, Tonelli M, Bahrami A, Eghbalnia HR, Center for Eukaryotic Structural Genomics (CESG)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155729 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription factor SOX-2 Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48431 (Residues: 39-118; Coverage: 25%)
Gene name: SOX2
Sequence domains: HMG (high mobility group) box
Structure domains: High mobility group box domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: molecular dynamics
Expression system: Escherichia coli

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