› 2l8h

Solution NMR

Chemical probe bound to HIV TAR RNA

Released:
DOI: 10.2210/pdb2l8h/pdb
PDB entry 2l8h coloured by chain, ensemble of 10 models, front view.
PDB entry 2l8h coloured by chain, ensemble of 10 models, side view.
PDB entry 2l8h coloured by chain, ensemble of 10 models, top view.
Source organism: synthetic construct
Primary publication:
A small-molecule probe induces a conformation in HIV TAR RNA capable of binding drug-like fragments.
Davidson A, Begley DW, Lau C, Varani G
J Mol Biol 410 984-96 (2011)
PMID: 21763501

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196453 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
HIV TAR RNA Chain: A
Molecule details ›
Chain: A
Length: 29 nucleotides
Theoretical weight: 9.31 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand ARG 1 x ARG
Ligand L8H 1 x L8H
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 30%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

11 review citations

The Emerging Role of RNA as a Therapeutic Target for Small Molecules.
Connelly et al. (2016)
10 more

11 mentions without citation

Structural and computational studies of HIV-1 RNA.
Levintov et al. (2024)
10 more