2kxp Summary


Solution NMR structure of V-1 bound to capping protein (CP)

A publication describing this structure is not available. The depositing authors are Zwolak, A.search; Fujiwara, I.search; Hammer III, J.A.search; Tjandra, N.search

The structure was determined using NMR spectroscopy and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely F-actin-capping protein subunit alpha-1, F-actin-capping protein subunit beta isoforms 1 and 2, and Myotrophin.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A F-actin-capping protein subunit alpha-1 P13127 (7-281) (CAZA1_CHICK)search Gallus gallussearch 96% 275 100%
B F-actin-capping protein subunit beta isoforms 1 and 2 P14315 (2-271) (CAPZB_CHICK)search Gallus gallussearch 97% 270 100%
C Myotrophin P62774 (1-118) (MTPN_MOUSE)search Mus musculussearch 100% 118 100%

This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P13127 (7 - 281) F-actin-capping protein subunit alpha-1 Gallus gallus
P14315 (2 - 271) F-actin-capping protein subunit beta isoforms 1 and 2 Gallus gallus
P62774 (1 - 118) Myotrophin Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A (P13127) PF01267: F-actin capping protein alpha subunitsearch
B (P14315) PF01115: F-actin capping protein, beta subunitsearch
C (P62774) Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch PF12796: Ankyrin repeats (3 copies)search

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P13127) cytoplasmsearch cytosolsearch WASH complexsearch Z discsearch actin bindingsearch actin filament cappingsearch
B (P14315) Z discsearch I bandsearch cortical cytoskeletonsearch membranesearch acrosomal vesiclesearch lamellipodiumsearch cytoplasmsearch cytoskeletonsearch F-actin capping protein complexsearch intercalated discsearch cytosolsearch beta-tubulin bindingsearch actin filament bindingsearch actin bindingsearch regulation of protein kinase C signalingsearch neuron projection developmentsearch actin filament cappingsearch lamellipodium assemblysearch muscle fiber developmentsearch cell projection organizationsearch negative regulation of microtubule polymerizationsearch barbed-end actin filament cappingsearch cytoskeleton organizationsearch regulation of cell morphogenesissearch
C (P62774) F-actin capping protein complexsearch cytoplasmsearch nucleussearch perinuclear region of cytoplasmsearch cytosolsearch axonsearch positive regulation of protein metabolic processsearch positive regulation of NF-kappaB transcription factor activitysearch positive regulation of cell growthsearch positive regulation of macromolecule biosynthetic processsearch catecholamine metabolic processsearch skeletal muscle tissue regenerationsearch striated muscle cell differentiationsearch cell growthsearch regulation of barbed-end actin filament cappingsearch cerebellar granule cell differentiationsearch positive regulation of cardiac muscle hypertrophysearch

Chain InterPro annotation
A F-actin-capping protein subunit alphasearch F-actin capping protein, alpha subunit, conserved sitesearch
B F-actin-capping protein subunit betasearch F-actin capping protein, beta subunit, conserved sitesearch
C Ankyrin repeatsearch Ankyrin repeat-containing domainsearch