2kxl Summary


Solution structure of a bacterial cyclic nucleotide-activated K+ channel binding domain in the unliganded state

The structure was published by Schunke, S., Stoldt, M., Lecher, J., Kaupp, U.B., and Willbold, D., in 2011 in a paper entitled "Structural insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1 channel." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cyclic nucleotide-gated potassium channel mll3241. This molecule has the UniProt identifier Q98GN8 (CNGK1_RHILO)search. The sample contained 142 residues which is < 90% of the natural sequence. Out of 142 residues 142 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 (216-355) (CNGK1_RHILO)search Mesorhizobium loti MAFF303099search 100% 142 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q98GN8 (216 - 355) Cyclic nucleotide-gated potassium channel mll3241 Mesorhizobium loti

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q98GN8) Jelly Rollssearch PF00027: Cyclic nucleotide-binding domainsearch, PF07885: Ion channelsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q98GN8) cAMP-dependent protein kinase regulator activitysearch regulation of protein phosphorylationsearch cAMP-dependent protein kinase complexsearch

Chain InterPro annotation
A Cyclic nucleotide-binding domainsearch cAMP/cGMP-dependent protein kinasesearch RmlC-like jelly roll foldsearch Cyclic nucleotide-binding, conserved sitesearch Cyclic nucleotide-binding-likesearch