2kso Summary

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EphA2:SHIP2 SAM:SAM complex

A publication describing this structure is not available. The depositing authors are Hota, P.K.search; Preeti, C.search; Stetzik, L.search; Kim, S.search; Wang, B.search; Lee, H.search; Buck, M.search

The structure was determined using NMR spectroscopy and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Ephrin type-A receptor 2 and Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ephrin type-A receptor 2 P29317 (908-972) (EPHA2_HUMAN)search Homo sapienssearch < 90% 82 79%
B Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 O15357 (1200-1258) (SHIP2_HUMAN)search Homo sapienssearch < 90% 76 77%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P29317 (908 - 972) Ephrin type-A receptor 2 Homo sapiens
O15357 (1200 - 1258) Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Transcription Factor, Ets-1search SAM domain (Sterile alpha motif)search
B Transcription Factor, Ets-1search SAM domain (Sterile alpha motif)search
Chain InterPro annotation
A Sterile alpha motif domainsearch Sterile alpha motif/pointed domainsearch Sterile alpha motif, type 1search
B Sterile alpha motif domainsearch Sterile alpha motif/pointed domainsearch Sterile alpha motif, type 1search