› 2krg

Solution NMR

Solution Structure of human sodium/ hydrogen exchange regulatory factor 1(150-358)

Released:
DOI: 10.2210/pdb2krg/pdb
PDB entry 2krg coloured by chain, ensemble of 20 models, front view.
PDB entry 2krg coloured by chain, ensemble of 20 models, side view.
PDB entry 2krg coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation.
Bhattacharya S, Dai Z, Li J, Baxter S, Callaway DJE, Cowburn D, Bu Z
J Biol Chem 285 9981-9994 (2010)
PMID: 20042604

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 23.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14745 (Residues: 150-358; Coverage: 58%)
Gene names: NHERF, NHERF1, SLC9A3R1
Sequence domains:
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures.
Ye et al. (2013)
12 more

3 mentions without citation

Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport.
Zhang et al. (2019)
2 more