› 2kmj

Solution NMR

High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry

Released:
DOI: 10.2210/pdb2kmj/pdb
PDB entry 2kmj coloured by chain, ensemble of 10 models, front view.
PDB entry 2kmj coloured by chain, ensemble of 10 models, side view.
PDB entry 2kmj coloured by chain, ensemble of 10 models, top view.
Source organisms:
Primary publication:
Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.
Ferner J, Suhartono M, Breitung S, Jonker HR, Hennig M, Wöhnert J, Göbel M, Schwalbe H
Chembiochem 10 1490-4 (2009)
PMID: 19444830

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-162834 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Pyrimidinylpeptide Chains: B, C
Molecule details ›
Chains: B, C
Length: 4 amino acids
Theoretical weight: 508 Da
Source organism: Synthetic construct
Expression system: Not provided
RNA (28-MER) Chain: A
Molecule details ›
Chain: A
Length: 28 nucleotides
Theoretical weight: 8.94 KDa
Source organism: Human immunodeficiency virus 2
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
1 modified residue:
Ligand DAR 4 x DAR

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Not provided
  • Escherichia coli

Quick links

Citations

2 review citations

Therapeutic targeting of HCV internal ribosomal entry site RNA.
Davis et al. (2011)
1 more

3 mentions without citation

Face-time with TAR: Portraits of an HIV-1 RNA with diverse modes of effector recognition relevant for drug discovery.
Chavali et al. (2019)
2 more