2kk6 Summary


Solution structure of sh2 domain of proto-oncogene tyrosine-protein kinase fer from homo sapiens, northeast structural genomics consortium (nesg) target hr3461d

A publication describing this structure is not available. The depositing authors are Tang, Y.search; Wang, D.search; Nwosu, C.search; Owens, L.search; Xiao, R.search; Liu, J.search; Baran, M.C.search; Swapna, G.search; Acton, T.B.search; Rost, B.search; Montelione, G.T.search; Northeast Structural Genomics Consortium (NESG)search

The structure was determined using NMR spectroscopy and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Proto-oncogene tyrosine-protein kinase FER. This molecule has the UniProt identifier P16591 (FER_HUMAN)search. The sample contained 116 residues which is < 90% of the natural sequence. Out of 116 residues 116 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase FER P16591 (453-557) (FER_HUMAN)search Homo sapienssearch < 90% 116 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P16591 (453 - 557) Proto-oncogene tyrosine-protein kinase FER Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A SHC Adaptor Proteinsearch SH2 domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P16591) regulation of epidermal growth factor receptor signaling pathwaysearch positive regulation of cell migrationsearch actin cytoskeleton reorganizationsearch positive regulation of NF-kappaB transcription factor activitysearch cell proliferationsearch epidermal growth factor receptor bindingsearch protein tyrosine kinase activitysearch

Chain InterPro annotation
A SH2 domainsearch Tyrosine-protein kinase Fersearch