› 2kf7

Solution NMR

Structure of a two-G-tetrad basket-type intramolecular G-quadruplex formed by human telomeric repeats in K+ solution (with G7-to-BRG substitution)

Released:
DOI: 10.2210/pdb2kf7/pdb
PDB entry 2kf7 coloured by chain, ensemble of 10 models, front view.
PDB entry 2kf7 coloured by chain, ensemble of 10 models, side view.
PDB entry 2kf7 coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers.
Lim KW, Amrane S, Bouaziz S, Xu W, Mu Y, Patel DJ, Luu KN, Phan AT
J Am Chem Soc 131 4301-9 (2009)
PMID: 19271707

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115473 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
HUMAN TELOMERE DNA Chain: A
Molecule details ›
Chain: A
Length: 22 nucleotides
Theoretical weight: 7.05 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand BGM 1 x BGM

Experiments and Validation Details

Entry percentile scores
Refinement method: matrix relaxation, molecular dynamics, DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

27 review citations

The structures of quadruplex nucleic acids and their drug complexes.
Neidle S. (2009)
26 more

3 mentions without citation

The many twists and turns of DNA: template, telomere, tool, and target.
Egli et al. (2010)
2 more