› 2k7y

Solution NMR

Solution fold of HIV-1 Virus protein U cytoplasmic domain in the presence of DPC micelles

Released:
DOI: 10.2210/pdb2k7y/pdb
PDB entry 2k7y coloured by chain, ensemble of 20 models, front view.
PDB entry 2k7y coloured by chain, ensemble of 20 models, side view.
PDB entry 2k7y coloured by chain, ensemble of 20 models, top view.
Source organism: Human immunodeficiency virus type 1 (SF162 ISOLATE)
Primary publication:
NMR structural characterization of HIV-1 virus protein U cytoplasmic domain in the presence of dodecylphosphatidylcholine micelles.
Wittlich M, Koenig BW, Stoldt M, Schmidt H, Willbold D
FEBS J 276 6560-75 (2009)
PMID: 19804408

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Vpu Chain: A
Molecule details ›
Chain: A
Length: 45 amino acids
Theoretical weight: 5.01 KDa
Source organism: Human immunodeficiency virus type 1 (SF162 ISOLATE)
Expression system: Escherichia coli
UniProt:
  • Canonical: P19554 (Residues: 39-81; Coverage: 53%)
Gene name: vpu
Sequence domains: Vpu protein
Structure domains: HIV-1 VPU cytoplasmic domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

4 review citations

HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms.
Andrew et al. (2010)
3 more

4 mentions without citation

Beyond Channel Activity: Protein-Protein Interactions Involving Viroporins.
To et al. (2018)
3 more