2k7o Summary

pdbe.org/2k7o
spacer

Ca2+-S100B, refined with RDCs

The structure was published by Wright, N.T., Inman, K.G., Levine, J.A., Cannon, B.R., Varney, K.M., and Weber, D.J., in 2008 in a paper entitled "Refinement of the solution structure and dynamic properties of Ca(2+)-bound rat S100B." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Protein S100-B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein S100-B P04631 (2-92) (S100B_RAT)search Rattus norvegicussearch 99% 91 100%
B Protein S100-B P04631 (2-92) (S100B_RAT)search Rattus norvegicussearch 99% 91 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04631 (2 - 92) Protein S100-B Rattus norvegicus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P04631) EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P04631) protein homodimerization activitysearch S100 protein bindingsearch calcium ion bindingsearch RAGE receptor bindingsearch zinc ion bindingsearch tau protein bindingsearch calcium-dependent protein bindingsearch receptor bindingsearch metal ion bindingsearch protein bindingsearch identical protein bindingsearch intracellular membrane-bounded organellesearch neuronal cell bodysearch nucleussearch extracellular spacesearch cytoplasmsearch rufflesearch perinuclear region of cytoplasmsearch positive regulation of apoptotic processsearch response to methylmercurysearch memorysearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch astrocyte differentiationsearch regulation of cell shapesearch learning or memorysearch cellular response to hypoxiasearch response to glucocorticoidsearch long-term synaptic potentiationsearch positive regulation of synaptic transmissionsearch regulation of neuronal synaptic plasticitysearch negative regulation of skeletal muscle cell differentiationsearch positive regulation of cell proliferationsearch

Chain InterPro annotation
A, B S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch