2k7a Summary

pdbe.org/2k7a
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Ensemble Structures of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase.

The structure was published by Severin, A.J., Joseph, R.E., Boyken, S., Fulton, D.B., and Andreotti, A.H., in 2009 in a paper entitled "Proline Isomerization Preorganizes the Itk SH2 Domain for Binding to the Itk SH3 Domain" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely SH3 domain of Tyrosine-protein kinase ITK/TSK and SH2 domain of Tyrosine-protein kinase ITK/TSK.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SH3 domain of Tyrosine-protein kinase ITK/TSK Q03526 (177-237) (ITK_MOUSE)search Mus musculussearch < 90% 63 100%
B SH2 domain of Tyrosine-protein kinase ITK/TSK Q03526 (238-344) (ITK_MOUSE)search Mus musculussearch < 90% 110 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q03526 (177 - 237) SH3 domain of Tyrosine-protein kinase ITK/TSK Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A SH3 Domainssearch SH3 domainsearch
B SHC Adaptor Proteinsearch SH2 domainsearch
Chain InterPro annotation
A SH3 domainsearch Spectrin alpha chain, SH3 domainsearch
B SH2 domainsearch