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Ensemble Structures of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase.

Solution NMR
PDB entry 2k7a coloured by chain, ensemble of 20 models, front view.
PDB entry 2k7a coloured by chain, ensemble of 20 models, side view.
PDB entry 2k7a coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase ITK/TSK
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Multimeric state: hetero dimer
Accessible surface area: 9595.42 Å2
Buried surface area: 1469.15 Å2
Dissociation area: 734.58 Å2
Dissociation energy (ΔGdiss): -2.71 kcal/mol
Dissociation entropy (TΔSdiss): 10.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169912

Macromolecules

Tyrosine-protein kinase ITK/TSK
Chain: A
Length: 63 amino acids
Theoretical weight: 7.36 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03526 (Residues: 177-237; Coverage: 10%)
Gene names: Emt, Itk, Tlk, Tsk
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
Tyrosine-protein kinase ITK/TSK in PDB entry 2k7a, assembly 1, front view.
Tyrosine-protein kinase ITK/TSK in PDB entry 2k7a, assembly 1, side view.
Tyrosine-protein kinase ITK/TSK in PDB entry 2k7a, assembly 1, top view.
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Tyrosine-protein kinase ITK/TSK
Chain: B
Length: 110 amino acids
Theoretical weight: 12.68 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03526 (Residues: 238-344; Coverage: 17%)
Gene names: Emt, Itk, Tlk, Tsk
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
Tyrosine-protein kinase ITK/TSK in PDB entry 2k7a, assembly 1, front view.
Tyrosine-protein kinase ITK/TSK in PDB entry 2k7a, assembly 1, side view.
Tyrosine-protein kinase ITK/TSK in PDB entry 2k7a, assembly 1, top view.
Molecule details ›

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