2k2f Summary


Solution structure of Ca2+-S100A1-RyRP12

The structure was published by Wright, N.T., Prosser, B.L., Varney, K.M., Zimmer, D.B., Schneider, M.F., and Weber, D.J., in 2008 in a paper entitled "S100A1 and Calmodulin Compete for the Same Binding Site on Ryanodine Receptor." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Ryanodine receptor 1 peptide and Protein S100-A1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C Ryanodine receptor 1 peptide B0LPN4 (3561-3572) (RYR2_RAT)search Rattus norvegicussearch < 90% 12 100%
D Ryanodine receptor 1 peptide B0LPN4 (3561-3572) (RYR2_RAT)search Rattus norvegicussearch < 90% 12 100%
A Protein S100-A1 P35467 (2-94) (S10A1_RAT)search Rattus norvegicussearch 99% 93 100%
B Protein S100-A1 P35467 (2-94) (S10A1_RAT)search Rattus norvegicussearch 99% 93 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
B0LPN4 (3561 - 3572) Ryanodine receptor 1 peptide Rattus norvegicus
P35467 (2 - 94) Protein S100-A1 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
C, D
A, B (P35467) S100 proteinssearch EF-handsearch PF00036: EF handsearch, PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P35467) calcium ion bindingsearch identical protein bindingsearch protein bindingsearch calcium-dependent protein bindingsearch S100 protein bindingsearch metal ion bindingsearch protein homodimerization activitysearch ATPase bindingsearch A bandsearch I bandsearch cytosolsearch M bandsearch nucleussearch neuron projectionsearch sarcoplasmic reticulumsearch cytoplasmsearch Z discsearch positive regulation of voltage-gated calcium channel activitysearch regulation of heart contractionsearch substantia nigra developmentsearch negative regulation of transcription from RNA polymerase II promotersearch

Chain InterPro annotation
C, D
A, B S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-A1search