2k0f Summary


Calmodulin complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase

The structure was published by Gsponer, J., Christodoulou, J., Cavalli, A., et al., Richter, B., Dobson, C.M., and Vendruscolo, M., in 2008 in a paper entitled "A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely calmodulin and 19-mer peptide from Myosin light chain kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A calmodulin P62158 (2-149) (CALM_HUMAN)search Homo sapienssearch 97% 148 95%
B 19-mer peptide from Myosin light chain kinase Q15746 (1742-1760) (MYLK_HUMAN)search Homo sapienssearch < 90% 19 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62158 (2 - 149) calmodulin Homo sapiens
Q15746 (1742 - 1760) 19-mer peptide from Myosin light chain kinase

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P62158) Calmodulin-likesearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P62158) cytosolsearch nucleoplasmsearch vesiclesearch spindlesearch plasma membranesearch nucleussearch spindle microtubulesearch cytoplasmsearch neuron projectionsearch spindle polesearch calcium channel complexsearch sarcomeresearch extracellular vesicular exosomesearch extracellular regionsearch cytoskeletonsearch growth conesearch centrosomesearch protein bindingsearch protein kinase bindingsearch protein domain specific bindingsearch calcium ion bindingsearch nitric-oxide synthase bindingsearch calcium-dependent protein bindingsearch phosphatidylinositol 3-kinase bindingsearch type 3 metabotropic glutamate receptor bindingsearch protein serine/threonine kinase activator activitysearch thioesterase bindingsearch phospholipase bindingsearch ion channel bindingsearch metal ion bindingsearch protein phosphatase activator activitysearch adenylate cyclase bindingsearch titin bindingsearch protein N-terminus bindingsearch nitric-oxide synthase regulator activitysearch enzyme regulator activitysearch N-terminal myristoylation domain bindingsearch positive regulation of phosphoprotein phosphatase activitysearch positive regulation of protein dephosphorylationsearch response to calcium ionsearch positive regulation of peptidyl-threonine phosphorylationsearch signal transductionsearch regulation of heart ratesearch fibroblast growth factor receptor signaling pathwaysearch carbohydrate metabolic processsearch G-protein coupled receptor signaling pathwaysearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch synaptic transmissionsearch response to corticosteronesearch inositol phosphate metabolic processsearch regulation of cytokinesissearch glucose metabolic processsearch negative regulation of peptidyl-threonine phosphorylationsearch positive regulation of protein serine/threonine kinase activitysearch phototransduction, visible lightsearch response to amphetaminesearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch positive regulation of nitric-oxide synthase activitysearch substantia nigra developmentsearch activation of phospholipase C activitysearch rhodopsin mediated signaling pathwaysearch platelet activationsearch Fc-epsilon receptor signaling pathwaysearch platelet degranulationsearch muscle contractionsearch detection of calcium ionsearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch blood coagulationsearch membrane organizationsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of nitric-oxide synthase activitysearch regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of high voltage-gated calcium channel activitysearch calcium-mediated signalingsearch epidermal growth factor receptor signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch activation of adenylate cyclase activitysearch small molecule metabolic processsearch positive regulation of protein autophosphorylationsearch regulation of rhodopsin mediated signaling pathwaysearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch positive regulation of cyclic nucleotide metabolic processsearch glycogen catabolic processsearch nitric oxide metabolic processsearch regulation of cardiac muscle contractionsearch innate immune responsesearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch