2k0e Summary


A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction

The structure was published by Gsponer, J., Christodoulou, J., Cavalli, A., et al., Richter, B., Dobson, C.M., and Vendruscolo, M., in 2008 in a paper entitled "A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Calmodulin. This molecule has the UniProt identifier P62158 (CALM_HUMAN)search. The sample contained 148 residues which is 99% of the natural sequence. Out of 148 residues 148 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calmodulin P62158 (2-149) (CALM_HUMAN)search Homo sapienssearch 97% 148 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62158 (2 - 149) Calmodulin Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P62158) Calmodulin-likesearch PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P62158) calcium ion bindingsearch protein bindingsearch phospholipase bindingsearch protein domain specific bindingsearch protein phosphatase activator activitysearch type 3 metabotropic glutamate receptor bindingsearch enzyme regulator activitysearch nitric-oxide synthase bindingsearch N-terminal myristoylation domain bindingsearch phosphatidylinositol 3-kinase bindingsearch ion channel bindingsearch thioesterase bindingsearch protein N-terminus bindingsearch adenylate cyclase bindingsearch metal ion bindingsearch calcium-dependent protein bindingsearch titin bindingsearch nitric-oxide synthase regulator activitysearch positive regulation of protein dephosphorylationsearch platelet degranulationsearch neurotrophin TRK receptor signaling pathwaysearch nitric oxide metabolic processsearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch inositol phosphate metabolic processsearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch platelet activationsearch activation of adenylate cyclase activitysearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch rhodopsin mediated signaling pathwaysearch innate immune responsesearch positive regulation of cyclic nucleotide metabolic processsearch positive regulation of phosphoprotein phosphatase activitysearch regulation of cardiac muscle contractionsearch positive regulation of nitric-oxide synthase activitysearch response to amphetaminesearch membrane organizationsearch regulation of nitric-oxide synthase activitysearch regulation of high voltage-gated calcium channel activitysearch regulation of cytokinesissearch activation of phospholipase C activitysearch regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch carbohydrate metabolic processsearch muscle contractionsearch G-protein coupled receptor signaling pathwaysearch substantia nigra developmentsearch synaptic transmissionsearch phototransduction, visible lightsearch calcium-mediated signalingsearch epidermal growth factor receptor signaling pathwaysearch regulation of heart ratesearch response to corticosteronesearch response to calcium ionsearch Fc-epsilon receptor signaling pathwaysearch glucose metabolic processsearch fibroblast growth factor receptor signaling pathwaysearch detection of calcium ionsearch blood coagulationsearch small molecule metabolic processsearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch glycogen catabolic processsearch signal transductionsearch regulation of rhodopsin mediated signaling pathwaysearch extracellular regionsearch cytosolsearch cytoplasmsearch spindlesearch cytoskeletonsearch plasma membranesearch nucleoplasmsearch sarcomeresearch spindle polesearch nucleussearch spindle microtubulesearch neuron projectionsearch calcium channel complexsearch centrosomesearch extracellular vesicular exosomesearch growth conesearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch