Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-128709 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Suppressor of cytokine signaling 3
Molecule details ›
Chain: A
Length: 40 amino acids
Theoretical weight: 4.57 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Length: 40 amino acids
Theoretical weight: 4.57 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical:
O35718 (Residues: 186-225; Coverage: 18%)
Elongin-B
Molecule details ›
Chain: B
Length: 118 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Length: 118 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q15370 (Residues: 1-118; Coverage: 100%)
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Elongin-C
Molecule details ›
Chain: C
Length: 96 amino acids
Theoretical weight: 10.84 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains: Skp1 family, tetramerisation domain
Structure domains: Potassium Channel Kv1.1; Chain A
Length: 96 amino acids
Theoretical weight: 10.84 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical: P83940 (Residues: 17-112; Coverage: 86%)
Sequence domains: Skp1 family, tetramerisation domain
Structure domains: Potassium Channel Kv1.1; Chain A
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Refinement method:
simulated annealing
Expression system: Escherichia coli
