› 2jyw

Solution NMR

Solution structure of C-terminal domain of APOBEC3G

Released:
DOI: 10.2210/pdb2jyw/pdb
PDB entry 2jyw coloured by chain, ensemble of 10 models, front view.
PDB entry 2jyw coloured by chain, ensemble of 10 models, side view.
PDB entry 2jyw coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G.
Chen KM, Harjes E, Gross PJ, Fahmy A, Lu Y, Shindo K, Harris RS, Matsuo H
Nature 452 116-9 (2008)
PMID: 18288108

Function and Biology Details

Reaction catalysed: 
Cytosine in single-stranded DNA + H(2)O = uracil in single-stranded DNA + NH(3)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190763 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA dC->dU-editing enzyme APOBEC-3G Chain: A
Molecule details ›
Chain: A
Length: 195 amino acids
Theoretical weight: 22.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HC16 (Residues: 198-384; Coverage: 49%)
Gene names: APOBEC3G, MDS019
Sequence domains: APOBEC-like C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

38 review citations

The AID/APOBEC family of nucleic acid mutators.
Conticello SG. (2008)
37 more

15 mentions without citation

A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket.
King et al. (2017)
14 more