› 2jyq

Solution NMR

NMR structure of the apo v-Src SH2 domain

Released:
DOI: 10.2210/pdb2jyq/pdb
PDB entry 2jyq coloured by chain, ensemble of 20 models, front view.
PDB entry 2jyq coloured by chain, ensemble of 20 models, side view.
PDB entry 2jyq coloured by chain, ensemble of 20 models, top view.
Source organism: Rous sarcoma virus
Primary publication:
Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: implications for drug design.
Taylor JD, Ababou A, Fawaz RR, Hobbs CJ, Williams MA, Ladbury JE
Proteins 73 929-40 (2008)
PMID: 18536014

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159032 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase transforming protein Src Chain: A
Molecule details ›
Chain: A
Length: 106 amino acids
Theoretical weight: 12.19 KDa
Source organism: Rous sarcoma virus
Expression system: Escherichia coli
UniProt:
  • Canonical: P63185 (Residues: 144-249; Coverage: 20%)
Gene name: V-SRC
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Peptidic modulators of protein-protein interactions: progress and challenges in computational design.
Rubinstein et al. (2009)
1 more

1 mention without citation

A back-door insight into the modulation of Src kinase activity by the polyamine spermidine.
Rossini et al. (2023)