2jxc Summary


Structure of the EPS15-EH2 Stonin2 Complex

The structure was published by Rumpf, J., Simon, B., Jung, N., et al., Haucke, V., Sattler, M., and Groemping, Y., in 2008 in a paper entitled "Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Epidermal growth factor receptor substrate 15 and Stonin-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Epidermal growth factor receptor substrate 15 P42566 (121-215) (EPS15_HUMAN)search Homo sapienssearch < 90% 100 95%
B Stonin-2 Q8WXE9 (301-340) (STON2_HUMAN)search Homo sapienssearch < 90% 45 88%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P42566 (121 - 215) Epidermal growth factor receptor substrate 15 Homo sapiens
Q8WXE9 (301 - 340) Stonin-2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Eps15 homology domain (EH domain)search EF-handsearch
B Stonin 2search

Chain ID Molecular function (GO)
A (P42566) calcium ion bindingsearch

Chain InterPro annotation
A EPS15 homology (EH)search EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch