› 2jwz

Solution NMR

Mutations in the hydrophobic core of ubiquitin differentially affect its recognition by receptor proteins

Released:
DOI: 10.2210/pdb2jwz/pdb
PDB entry 2jwz coloured by chain, ensemble of 10 models, front view.
PDB entry 2jwz coloured by chain, ensemble of 10 models, side view.
PDB entry 2jwz coloured by chain, ensemble of 10 models, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Mutations in the hydrophobic core of ubiquitin differentially affect its recognition by receptor proteins.
Haririnia A, Verma R, Purohit N, Twarog MZ, Deshaies RJ, Bolon D, Fushman D
J Mol Biol 375 979-96 (2008)
PMID: 18054791

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143464 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 8.54 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P0CG63 (Residues: 305-380; Coverage: 20%)
Gene names: SCD2, UBI4, YLL039C
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

4 review citations

The diversity of ubiquitin recognition: hot spots and varied specificity.
Winget et al. (2010)
3 more

2 mentions without citation

Mutations in the hydrophobic core of ubiquitin differentially affect its recognition by receptor proteins.
Haririnia et al. (2008)
1 more