Structure analysis

ErbB2 transmembrane segment dimer spatial structure

Solution NMR
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 8439.54 Å2
Buried surface area: 1281.85 Å2
Dissociation area: 640.92 Å2
Dissociation energy (ΔGdiss): 5.24 kcal/mol
Dissociation entropy (TΔSdiss): 10.42 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138084

Macromolecules

Chains: A, B
Length: 44 amino acids
Theoretical weight: 4.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04626 (Residues: 641-684; Coverage: 4%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL
Pfam: Epidermal growth factor receptor transmembrane-juxtamembrane segment
CATH: Cytochrome c1, transmembrane anchor, C-terminal

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