2jtt Summary


Solution structure of calcium loaded S100A6 bound to C-terminal Siah-1 interacting protein

The structure was published by Lee, Y.T., Dimitrova, Y.N., Schneider, G., et al., Caprioli, R.M., Filipek, A., and Chazin, W.J., in 2008 in a paper entitled "Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Protein S100-A6 and Calcyclin-binding protein.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein S100-A6 P30801 (1-90) (S10A6_RABIT)search Oryctolagus cuniculussearch 100% 90 100%
B Protein S100-A6 P30801 (1-90) (S10A6_RABIT)search Oryctolagus cuniculussearch 100% 90 100%
C Calcyclin-binding protein Q9CXW3 (189-219) (CYBP_MOUSE)search Mus musculussearch < 90% 35 88%
D Calcyclin-binding protein Q9CXW3 (189-219) (CYBP_MOUSE)search Mus musculussearch < 90% 35 88%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P30801 (1 - 90) Protein S100-A6 Oryctolagus cuniculus
Q9CXW3 (189 - 219) Calcyclin-binding protein Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P30801) S100 proteinssearch EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch
C, D SGS domainsearch

Chain ID Cellular component (GO) Molecular function (GO)
A, B (P30801) cytosolsearch membranesearch plasma membranesearch extrinsic component of cytoplasmic side of plasma membranesearch perinuclear region of cytoplasmsearch rufflesearch nuclear envelopesearch nucleussearch cytoplasmsearch extracellular vesicular exosomesearch calcium ion bindingsearch calcium-dependent protein bindingsearch protein homodimerization activitysearch protein N-terminus bindingsearch tropomyosin bindingsearch S100 protein bindingsearch metal ion bindingsearch zinc ion bindingsearch

Chain InterPro annotation
A, B S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch
C, D SGSsearch