2js2 Summary


Solution structure of first SH3 domain of adaptor Nck

The structure was published by Hake, M.J., Choowongkomon, K., Kostenko, O., Carlin, C.R., and Sonnichsen, F.D., in 2008 in a paper entitled "Specificity determinants of a novel Nck interaction with the juxtamembrane domain of the epidermal growth factor receptor." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cytoplasmic protein NCK1. This molecule has the UniProt identifier P16333 (NCK1_HUMAN)search. The sample contained 63 residues which is < 90% of the natural sequence. Out of 63 residues 63 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cytoplasmic protein NCK1 P16333 (1-61) (NCK1_HUMAN)search Homo sapienssearch < 90% 63 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P16333 (1 - 61) Cytoplasmic protein NCK1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A SH3 Domainssearch SH3 domainsearch

Chain ID Molecular function (GO)
A (P16333) protein kinase regulator activitysearch

Chain InterPro annotation
A SH3 domainsearch Cytoplasmic protein NCK1search