› 2jp2

Solution NMR

Solution structure and resonance assignment of the N-terminal EVH1 domain from the human Spred2 protein (Sprouty-related protein with EVH1 domain isoform 2)

Released:
DOI: 10.2210/pdb2jp2/pdb
PDB entry 2jp2 coloured by chain, ensemble of 20 models, front view.
PDB entry 2jp2 coloured by chain, ensemble of 20 models, side view.
PDB entry 2jp2 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain.
Zimmermann J, Jarchau T, Walter U, Oschkinat H, Ball LJ
J Biomol NMR 29 435-6 (2004)
PMID: 15213456

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182284 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sprouty-related, EVH1 domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z698 (Residues: 1-124; Coverage: 30%)
Gene name: SPRED2
Sequence domains: WH1 domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Getting a first clue about SPRED functions.
Bundschu et al. (2007)
1 other article

3 mentions without citation

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.
Gileadi et al. (2007)
2 more