2jmo Summary


IBR domain of Human Parkin

The structure was published by Beasley, S.A., Hristova, V.A., and Shaw, G.S., in 2007 in a paper entitled "Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Parkin. This molecule has the UniProt identifier O60260 (PRKN2_HUMAN)search. The sample contained 80 residues which is < 90% of the natural sequence. Out of 80 residues 80 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Parkin O60260 (308-384) (PRKN2_HUMAN)search Homo sapienssearch < 90% 80 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O60260 (308 - 384) Parkin Homo sapiens

Chain Sequence family (Pfam)
A IBR domainsearch

Chain ID Molecular function (GO)
A (O60260) zinc ion bindingsearch

Chain InterPro annotation
A Zinc finger, C6HC-typesearch