› 2jlp

X-ray diffraction
1.7Å resolution

Crystal structure of human extracellular copper-zinc superoxide dismutase.

Released:
DOI: 10.2210/pdb2jlp/pdb
PDB entry 2jlp coloured by chain, front view.
PDB entry 2jlp coloured by chain, side view.
PDB entry 2jlp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding.
Antonyuk SV, Strange RW, Marklund SL, Hasnain SS
J Mol Biol 388 310-26 (2009)
PMID: 19289127

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140087 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Extracellular superoxide dismutase [Cu-Zn] Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 222 amino acids
Theoretical weight: 24.2 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08294 (Residues: 19-240; Coverage: 100%)
Gene name: SOD3
Sequence domains: Copper/zinc superoxide dismutase (SODC)
Structure domains: Superoxide dismutase, copper/zinc binding domain

Ligands and Environments

3 bound ligands:
Ligand CU 4 x CU
Ligand ZN 4 x ZN
Ligand SCN 2 x SCN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX10.1
Spacegroup: P21
Unit cell:
a: 56.738Å b: 93.588Å c: 75.6Å
α: 90° β: 106.23° γ: 90°
R-values:
R R work R free
0.152 0.15 0.185
Expression system: Cricetulus griseus

Quick links

Citations

21 review citations

Superoxide dismutases: role in redox signaling, vascular function, and diseases.
Fukai et al. (2011)
20 more

12 mentions without citation

Silver Ions as a Tool for Understanding Different Aspects of Copper Metabolism.
Puchkova et al. (2019)
11 more