› 2jln

X-ray diffraction
2.85Å resolution

Structure of Mhp1, a nucleobase-cation-symport-1 family transporter

Released:
DOI: 10.2210/pdb2jln/pdb
PDB entry 2jln coloured by chain, front view.
PDB entry 2jln coloured by chain, side view.
PDB entry 2jln coloured by chain, top view.
Source organism: Microbacterium liquefaciens
Primary publication:
Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter.
Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PC, Iwata S, Henderson PJ, Cameron AD
Science 322 709-13 (2008)
PMID: 18927357

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112805 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hydantoin permease Chain: A
Molecule details ›
Chain: A
Length: 501 amino acids
Theoretical weight: 54.62 KDa
Source organism: Microbacterium liquefaciens
Expression system: Escherichia coli
UniProt:
  • Canonical: D6R8X8 (Residues: 1-488; Coverage: 100%)
Gene name: hyuP
Sequence domains: Permease for cytosine/purines, uracil, thiamine, allantoin
Structure domains: Hydantoin permease

Ligands and Environments

2 bound ligands:
Ligand NA 1 x NA
Ligand HG 1 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 79.7Å b: 109.14Å c: 113.82Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.234 0.281
Expression system: Escherichia coli

Quick links

Citations

49 review citations

Biology of human sodium glucose transporters.
Wright et al. (2011)
48 more

45 mentions without citation

Unlocking the molecular secrets of sodium-coupled transporters.
Krishnamurthy et al. (2009)
44 more