2jld Summary

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EXTREMELY TIGHT BINDING OF RUTHENIUM COMPLEX TO GLYCOGEN SYNTHASE KINASE 3

The structure was published by Atilla-Gokcumen, G.E., Pagano, N., Streu, C., et al., Filippakopoulos, P., Knapp, S., and Meggers, E., in 2008 in a paper entitled "Extremely Tight Binding of a Ruthenium Complex to Glycogen Synthase Kinase 3." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely GLYCOGEN SYNTHASE KINASE-3 BETA and PEPTIDE (ALA-GLY-GLY-ALA-ALA-ALA-ALA-ALA).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 83%
B GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 83%
E PEPTIDE (ALA-GLY-GLY-ALA-ALA-ALA-ALA-ALA) Not available
Not available Not available 8 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) GLYCOGEN SYNTHASE KINASE-3 BETA Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
E

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) protein phosphorylationsearch hypermethylation of CpG islandsearch cell differentiationsearch positive regulation of protein bindingsearch superior temporal gyrus developmentsearch cellular response to mechanical stimulussearch regulation of neuronal synaptic plasticitysearch canonical Wnt signaling pathwaysearch fat cell differentiationsearch response to lithium ionsearch cell migrationsearch circadian rhythmsearch epithelial to mesenchymal transitionsearch negative regulation of glycogen (starch) synthase activitysearch peptidyl-serine phosphorylationsearch rhythmic processsearch carbohydrate metabolic processsearch positive regulation of transcription from RNA polymerase II promotersearch neurotrophin TRK receptor signaling pathwaysearch phosphorylationsearch negative regulation of dendrite morphogenesissearch intracellular signal transductionsearch axon guidancesearch glycogen metabolic processsearch ER overload responsesearch negative regulation of cardiac muscle hypertrophysearch negative regulation of glycogen biosynthetic processsearch negative regulation of type B pancreatic cell developmentsearch positive regulation of Rac GTPase activitysearch protein export from nucleussearch Fc-epsilon receptor signaling pathwaysearch regulation of microtubule-based processsearch negative regulation of apoptotic processsearch response to drugsearch fibroblast growth factor receptor signaling pathwaysearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch innate immune responsesearch phosphatidylinositol-mediated signalingsearch myoblast fusionsearch organ morphogenesissearch positive regulation of protein export from nucleussearch axonogenesissearch extrinsic apoptotic signaling pathway in absence of ligandsearch negative regulation of NFAT protein import into nucleussearch positive regulation of apoptotic processsearch positive regulation of stem cell differentiationsearch establishment of cell polaritysearch Wnt signaling pathwaysearch protein localization to microtubulesearch positive regulation of peptidyl-serine phosphorylationsearch multicellular organismal developmentsearch positive regulation of protein complex assemblysearch negative regulation of signal transductionsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch regulation of gene expression by genetic imprintingsearch negative regulation of canonical Wnt signaling pathwaysearch myotube differentiationsearch positive regulation of peptidyl-threonine phosphorylationsearch re-entry into mitotic cell cyclesearch negative regulation of MAP kinase activitysearch nervous system developmentsearch negative regulation of protein complex assemblysearch negative regulation of protein bindingsearch hippocampus developmentsearch positive regulation of protein catabolic processsearch cellular response to interleukin-3search positive regulation of cell-matrix adhesionsearch epidermal growth factor receptor signaling pathwaysearch establishment or maintenance of cell polaritysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch protein bindingsearch tau-protein kinase activitysearch kinase activitysearch protein kinase bindingsearch transferase activitysearch ionotropic glutamate receptor bindingsearch NF-kappaB bindingsearch nucleotide bindingsearch ubiquitin protein ligase bindingsearch beta-catenin bindingsearch p53 bindingsearch integrin bindingsearch tau protein bindingsearch RNA polymerase II transcription factor bindingsearch protein kinase A catalytic subunit bindingsearch cytosolsearch plasma membranesearch nucleussearch cytoplasmsearch beta-catenin destruction complexsearch membrane-bounded organellesearch membrane raftsearch membranesearch dendritic shaftsearch ribonucleoprotein complexsearch centrosomesearch neuronal cell bodysearch perinuclear region of cytoplasmsearch dendritic spinesearch growth conesearch protein complexsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
E