› 2jk6

X-ray diffraction
2.95Å resolution

Structure of Trypanothione Reductase from Leishmania infantum

Released:
DOI: 10.2210/pdb2jk6/pdb
PDB entry 2jk6 coloured by chain, front view.
PDB entry 2jk6 coloured by chain, side view.
PDB entry 2jk6 coloured by chain, top view.
Source organism: Leishmania infantum
Primary publication:
Molecular basis of antimony treatment in leishmaniasis.
Baiocco P, Colotti G, Franceschini S, Ilari A
J Med Chem 52 2603-12 (2009)
PMID: 19317451

Function and Biology Details

Reaction catalysed: 
Trypanothione + NADP(+) = trypanothione disulfide + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trypanothione reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 511 amino acids
Theoretical weight: 55.26 KDa
Source organism: Leishmania infantum
Expression system: Escherichia coli
UniProt:
  • Canonical: A4HSF7 (Residues: 1-491; Coverage: 100%)
Gene names: LINJ_05_0350, TRYR
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P41
Unit cell:
a: 103.451Å b: 103.451Å c: 192.621Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.235 0.264
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Pentavalent antimonials: new perspectives for old drugs.
Frézard et al. (2009)
23 more

32 mentions without citation

Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases.
Battista et al. (2020)
31 more