2jj3 Summary

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ESTROGEN RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH A BENZOPYRAN AGONIST

The structure was published by Norman, B.H., Richardson, T.I., Dodge, J.A., et al., Liu, S., Reilly, J.E., and Ryter, K.T., in 2007 in a paper entitled "Benzopyrans as Selective Estrogen Receptor Beta Agonists (Serbas). Part 4: Functionalization of the Benzopyran A-Ring." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.28 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of ESTROGEN RECEPTOR BETA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ESTROGEN RECEPTOR BETA Q92731 (256-505) (ESR2_HUMAN)search Homo sapienssearch < 90% 257 88%
B ESTROGEN RECEPTOR BETA Q92731 (256-505) (ESR2_HUMAN)search Homo sapienssearch < 90% 257 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q92731 (256 - 505) ESTROGEN RECEPTOR BETA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (Q92731) nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch thyroid hormone receptor activitysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch