› 2jih

X-ray diffraction
2.1Å resolution

Crystal Structure of Human ADAMTS-1 catalytic Domain and Cysteine- Rich Domain (complex-form)

Released:
DOI: 10.2210/pdb2jih/pdb
PDB entry 2jih coloured by chain, front view.
PDB entry 2jih coloured by chain, side view.
PDB entry 2jih coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains.
Gerhardt S, Hassall G, Hawtin P, McCall E, Flavell L, Minshull C, Hargreaves D, Ting A, Pauptit RA, Parker AE, Abbott WM
J Mol Biol 373 891-902 (2007)
PMID: 17897672

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193751 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
A disintegrin and metalloproteinase with thrombospondin motifs 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 300 amino acids
Theoretical weight: 32.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UHI8 (Residues: 253-548; Coverage: 32%)
Gene names: ADAMTS1, KIAA1346, METH1
Sequence domains:
Structure domains:

Ligands and Environments

6 bound ligands:
Ligand 097 2 x 097
Ligand ZN 2 x ZN
Ligand CD 6 x CD
Ligand NI 12 x NI
Ligand MG 6 x MG
Ligand NA 5 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 51.579Å b: 64.396Å c: 113.524Å
α: 90° β: 90.91° γ: 90°
R-values:
R R work R free
0.227 0.224 0.282
Expression system: Spodoptera frugiperda

Quick links

Citations

10 review citations

The ADAM metalloproteinases.
Edwards et al. (2008)
9 more

5 mentions without citation

ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview.
Takeda S. (2016)
4 more