2jh5 Summary

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Human Thrombin Hirugen Inhibitor complex.

The structure was published by Senger, S., Chan, C., Convery, M.A., et al., Shah, G.P., Watson, N.S., and Young, R.J., in 2007 in a paper entitled "Sulfonamide-Related Conformational Effects and Their Importance in Structure-Based Design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, and HIRUDIN IIIA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C THROMBIN LIGHT CHAIN P00734 (328-363) (THRB_HUMAN)search Homo sapienssearch 93% 36 77%
D THROMBIN HEAVY CHAIN P00734 (364-622) (THRB_HUMAN)search Homo sapienssearch 93% 259 96%
H HIRUDIN IIIA P28507 (55-64) (HIR3A_HIRME)search Hirudo medicinalissearch < 90% 10 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00734 (328 - 363) THROMBIN LIGHT CHAIN Homo sapiens
P28507 (55 - 64) HIRUDIN IIIA HIRUDO MEDICINALIS

Chain Structural classification (CATH) Sequence family (Pfam)
C (P00734) PF09396: Thrombin light chainsearch
D (P00734) Trypsin-like serine proteasessearch PF00089: Trypsinsearch
H Hirudinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
C (P00734) extracellular regionsearch serine-type endopeptidase activitysearch blood coagulationsearch proteolysissearch
D (P00734) calcium ion bindingsearch serine-type endopeptidase activitysearch catalytic activitysearch proteolysissearch blood coagulationsearch

Chain InterPro annotation
C Thrombin light chainsearch
D Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Prothrombin/thrombinsearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
H