2jgz Summary

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CRYSTAL STRUCTURE OF PHOSPHO-CDK2 IN COMPLEX WITH CYCLIN B

The structure was published by Brown, N.R., Lowe, E.D., Petri, E., Skamnaki, V., Antrobus, R., and Johnson, L.N., in 2007 in a paper entitled "Cyclin B and Cyclin a Confer Different Substrate Recognition Properties on Cdk2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and G2/MITOTIC-SPECIFIC CYCLIN-B1.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-288) (CDK2_HUMAN)search Homo sapienssearch 97% 289 100%
B G2/MITOTIC-SPECIFIC CYCLIN-B1 P14635 (167-426) (CCNB1_HUMAN)search Homo sapienssearch < 90% 260 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 288) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P14635 (167 - 426) G2/MITOTIC-SPECIFIC CYCLIN-B1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch cyclin bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch nucleotide bindingsearch kinase activitysearch histone kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch metal ion bindingsearch protein phosphorylationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch Ras protein signal transductionsearch mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch meiotic cell cyclesearch mitotic G1 DNA damage checkpointsearch histone phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch positive regulation of cell proliferationsearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic nuclear divisionsearch G2/M transition of mitotic cell cyclesearch centrosome duplicationsearch meiotic nuclear divisionsearch G1/S transition of mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch DNA replicationsearch phosphorylationsearch DNA repairsearch cellular response to DNA damage stimulussearch regulation of gene silencingsearch cellular response to nitric oxidesearch potassium ion transportsearch cell cyclesearch blood coagulationsearch cell divisionsearch Cajal bodysearch nucleussearch transcription factor complexsearch nucleoplasmsearch cytosolsearch endosomesearch condensed chromosomesearch cytoskeletonsearch chromosome, telomeric regionsearch cytoplasmsearch Y chromosomesearch X chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch centrosomesearch
B (P14635) nucleussearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch