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EBI PDBe PDBeView

PDBe Entry: 2jgf view

CRYSTAL STRUCTURE OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY NON-AGED FENAMIPHOS
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.5 Å, R-factor: 21.5%, Free R-factor: 25.3%, Spacegroup: P 21 21 21
Released 17/04/2007, deposition: 13/02/2007, last revision: 24/02/2009
Authors Hornberg, A.search; Tunemalm, A.-K.search; Ekstrom, F.search
Primary citation Crystal Structures of Acetylcholinesterase in Complex with Organophosphorus Compounds Suggest that the Acyl Pocket Modulates the Aging Reaction by Precluding the Formation of the Trigonal Bipyramidal Transition State.
BIOCHEMISTRYsearch vol:46, pag:4815 (2007) [PubMed ID 17402711 ]search
Keywords GLYCOPROTEINsearch, SERINE ESTERASEsearch, ACETYLCHOLINESTERASEsearch, ALTERNATIVE SPLICINGsearch, NEUROTRANSMITTER DEGRADATIONsearch, SYNAPSEsearch, MEMBRANEsearch, HYDROLASEsearch, FENAMIPHOSsearch
EC 3.1.1.7 ExPASy BRENDA search (A B)
Organism Mus musculus(house mouse) 10090search(A B)
UniProt Acetylcholinesterase precursor (EC 3.1.1.7) (AChE) P21836search (A B)
Solvent A, B
Related entries 1c2b, 1c2o, 1j06, 1j07, 1ku6, 1maa, 1mah, 1n5m, 1n5r, 1q83, 1q84, 2c0p, 2c0q, 2h9y, 2ha0, 2ha2, 2ha3, 2ha4, 2ha5, 2ha6, 2ha7, 2jey, 2jez, 2jf0, 2jge, 2jgg, 2jgh, 2jgi, 2jgj, 2jgk, 2jgl, 2jgm
Polymers
Id Name Type UniProt Residues Observed
A, B ACETYLCHOLINESTERASE Protein P21836 (ACES_MOUSE)search
 548 97%
Heterogens
Id Name Ligands
A SUGAR (N-ACETYL-D-GLUCOSAMINE) NAG search
A HEXAETHYLENE GLYCOL P6G search
A TRIETHYLENE GLYCOL PGE search
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