2jf9 Summary

pdbe.org/2jf9
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ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH A TAMOXIFEN-SPECIFIC PEPTIDE ANTAGONIST

The structure was published by Heldring, N., Pawson, T., Mcdonnell, D., Treuter, E., Gustafsson, J.A., and Pike, A.C.W., in 2007 in a paper entitled "Structural Insights Into Corepressor Recognition by Antagonist-Bound Estrogen Receptors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely ESTROGEN RECEPTOR and AB5 PEPTIDE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ESTROGEN RECEPTOR P03372 (304-533) (ESR1_HUMAN)search Homo sapienssearch < 90% 252 85%
B ESTROGEN RECEPTOR P03372 (304-533) (ESR1_HUMAN)search Homo sapienssearch < 90% 252 85%
C ESTROGEN RECEPTOR P03372 (304-533) (ESR1_HUMAN)search Homo sapienssearch < 90% 252 85%
P AB5 PEPTIDE Not available
Synthetic Not available 13 100%
Q AB5 PEPTIDE Not available
Synthetic Not available 13 100%
R AB5 PEPTIDE Not available
Synthetic Not available 13 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03372 (304 - 533) ESTROGEN RECEPTOR Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
P, Q, R

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C (P03372) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B, C Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
P, Q, R