2jcw Summary

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PDB entry 2jcw (supersedes 1jcw)

REDUCED BRIDGE-BROKEN YEAST CU/ZN SUPEROXIDE DISMUTASE ROOM TEMPERATURE (298K) STRUCTURE

The structure was published by Hart, P.J., Balbirnie, M.M., Ogihara, N.L., et al., Weiss, M.S., Valentine, J.S., and Eisenberg, D., in 1999 in a paper entitled "A structure-based mechanism for copper-zinc superoxide dismutase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CU/ZN SUPEROXIDE DISMUTASE. This molecule has the UniProt identifier P00445 (SODC_YEAST)search. The sample contained 153 residues which is 99% of the natural sequence. Out of 153 residues 153 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CU/ZN SUPEROXIDE DISMUTASE P00445 (2-154) (SODC_YEAST)search Saccharomyces cerevisiae S288csearch 99% 153 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00445 (2 - 154) CU/ZN SUPEROXIDE DISMUTASE Saccharomyces cerevisiae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00445) Cu,Zn superoxide dismutase-likesearch Immunoglobulin-likesearch PF00080: Copper/zinc superoxide dismutase (SODC)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00445) metal ion bindingsearch superoxide dismutase activitysearch protein bindingsearch oxidoreductase activitysearch antioxidant activitysearch oxidation-reduction processsearch superoxide metabolic processsearch cellular zinc ion homeostasissearch protein stabilizationsearch cellular copper ion homeostasissearch age-dependent response to reactive oxygen species involved in chronological cell agingsearch negative regulation of cellular respirationsearch positive regulation of sequence-specific DNA binding transcription factor activitysearch removal of superoxide radicalssearch fungal-type cell wall organizationsearch positive regulation of transcription from RNA polymerase II promoter in response to oxidative stresssearch nucleussearch cytosolsearch cytoplasmsearch mitochondrionsearch mitochondrial intermembrane spacesearch

Chain InterPro annotation
A Superoxide dismutase, copper/zinc binding domainsearch Superoxide dismutase, copper/zinc, binding sitesearch