2jcw Summary


PDB entry 2jcw (supersedes 1jcw)


The structure was published by Hart, P.J., Balbirnie, M.M., Ogihara, N.L., et al., Weiss, M.S., Valentine, J.S., and Eisenberg, D., in 1999 in a paper entitled "A structure-based mechanism for copper-zinc superoxide dismutase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CU/ZN SUPEROXIDE DISMUTASE. This molecule has the UniProt identifier P00445 (SODC_YEAST)search. The sample contained 153 residues which is 99% of the natural sequence. Out of 153 residues 153 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CU/ZN SUPEROXIDE DISMUTASE P00445 (2-154) (SODC_YEAST)search Saccharomyces cerevisiae S288csearch 99% 153 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00445 (2 - 154) CU/ZN SUPEROXIDE DISMUTASE Saccharomyces cerevisiae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00445) Cu,Zn superoxide dismutase-likesearch Immunoglobulin-likesearch PF00080: Copper/zinc superoxide dismutase (SODC)search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00445) protein stabilizationsearch superoxide metabolic processsearch cellular zinc ion homeostasissearch oxidation-reduction processsearch age-dependent response to reactive oxygen species involved in chronological cell agingsearch cellular copper ion homeostasissearch removal of superoxide radicalssearch negative regulation of cellular respirationsearch fungal-type cell wall organizationsearch positive regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of transcription from RNA polymerase II promoter in response to oxidative stresssearch superoxide dismutase activitysearch metal ion bindingsearch oxidoreductase activitysearch protein bindingsearch antioxidant activitysearch nucleussearch cytosolsearch mitochondrionsearch mitochondrial intermembrane spacesearch cytoplasmsearch

Chain InterPro annotation
A Superoxide dismutase, copper/zinc binding domainsearch Superoxide dismutase, copper/zinc, binding sitesearch