2jbp Summary

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PROTEIN KINASE MK2 IN COMPLEX WITH AN INHIBITOR (CRYSTAL FORM-2, CO-CRYSTALLIZATION)

The structure was published by Hillig, R.C., Eberspaecher, U., Monteclaro, F., et al., Mengel, A., Muller-Tiemann, B., and Egner, U., in 2007 in a paper entitled "Structural Basis for a High Affinity Inhibitor Bound to Protein Kinase Mk2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.31 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of MAP KINASE-ACTIVATED PROTEIN KINASE 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MAP KINASE-ACTIVATED PROTEIN KINASE 2 P49137 (41-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 326 88%
B MAP KINASE-ACTIVATED PROTEIN KINASE 2 P49137 (41-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 326 88%
C MAP KINASE-ACTIVATED PROTEIN KINASE 2 P49137 (41-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 326 88%
D MAP KINASE-ACTIVATED PROTEIN KINASE 2 P49137 (41-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 326 88%
E MAP KINASE-ACTIVATED PROTEIN KINASE 2 P49137 (41-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 326 88%
F MAP KINASE-ACTIVATED PROTEIN KINASE 2 P49137 (41-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 326 88%
G MAP KINASE-ACTIVATED PROTEIN KINASE 2 P49137 (41-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 326 88%
H MAP KINASE-ACTIVATED PROTEIN KINASE 2 P49137 (41-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 326 88%
I MAP KINASE-ACTIVATED PROTEIN KINASE 2 P49137 (41-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 326 88%
J MAP KINASE-ACTIVATED PROTEIN KINASE 2 P49137 (41-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 326 88%
K MAP KINASE-ACTIVATED PROTEIN KINASE 2 P49137 (41-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 326 88%
L MAP KINASE-ACTIVATED PROTEIN KINASE 2 P49137 (41-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 326 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49137 (41 - 364) MAP KINASE-ACTIVATED PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J, K, L (P49137) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D, E, F, G, H, I, J, K, L (P49137) protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J, K, L Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch MAP kinase activated protein kinase, C-terminal domainsearch