2jav Summary

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PDB entry 2jav (supersedes 2cl1)

HUMAN KINASE WITH PYRROLE-INDOLINONE LIGAND

The structure was published by Rellos, P., Ivins, F.J., Baxter, J.E., et al., Fry, A.M., Knapp, S., and Smerdon, S.J., in 2007 in a paper entitled "Structure and Regulation of the Human Nek2 Centrosomal Kinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of SERINE/THREONINE-PROTEIN KINASE NEK2. This molecule has the UniProt identifier P51955 (NEK2_HUMAN)search. The sample contained 279 residues which is < 90% of the natural sequence. Out of 279 residues 245 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SERINE/THREONINE-PROTEIN KINASE NEK2 P51955 (1-271) (NEK2_HUMAN)search Homo sapienssearch < 90% 279 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P51955 (1 - 271) SERINE/THREONINE-PROTEIN KINASE NEK2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P51955) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch